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Regeneration [Pdf/ePub] eBook ISBN-10: 014190643X
Author: ,
Publisher: Penguin UK
File Size: 884 KB
File Format: Pdf
Read Count: 1290493


Regeneration by , Book Resume:

A powerfully moving modern classic from one of Britain's greatest living storytellers - the bestselling, Booker Prize-winning author of The Silence of the Girls Recommended by Richard Osman Regeneration is a masterful and richly immersive portrait of extraordinary lives played out in the shadow of the First World War... 'Unforgettable' Sunday Telegraph Craiglockhart War Hospital, Scotland, 1917, and army psychiatrist William Rivers is treating shell-shocked soldiers. Under his care are the poets Siegfried Sassoon and Wilfred Owen, as well as mute Billy Prior, who is only able to communicate by means of pencil and paper. Rivers's job is to make the men in his charge healthy enough to fight. Yet the closer he gets to mending his patients' minds the harder becomes every decision to send them back to the horrors of the front. Pat Barker's Regeneration is the classic exploration of how the traumas of war brutalised a generation of young men. 'One of the strongest and most interesting novelists of her generation' Guardian Regeneration is the first novel in Pat Barker's essential trilogy about the First World War. Discover the whole trilogy: Regeneration The Eye in the Door The Ghost Road


Regenerate [Pdf/ePub] eBook ISBN-10: 1401956408
Author: Sayer Ji
Publisher: Hay House, Inc
File Size: 587 KB
File Format: Pdf
Read Count: 1577053


Regenerate by Sayer Ji Book Resume:

"This book is a revolution! It goes way beyond the beliefs that have fueled modern pharmaceutical medicine for decades and gives you all the science you'll ever need to prove that there is another way." - Christiane Northrup, M.D., New York Times bestselling author of Goddesses Never Age Modern medicine and human health are at a critical crossroads, and the truth is that you and not your genes are in the driver's seat. You are the one who gets to make informed decisions on how you use and nourish the evolutionary miracle that is your body. Combining analysis of cutting-edge scientific findings with our deepest ancestral wisdom and health-promoting practices, Sayer Ji, founder of GreenMedInfo, offers a time-tested program to help prevent and manage the most common health afflictions of our day-cancer, heart disease, neurodegenerative diseases, and metabolic syndrome. Antiquated thinking and scientific dogma have long obstructed our understanding of our innate untapped potential for self-regeneration and radical healing. But the New Biology explains why biological time is not a downward spiral and how chronic illness is not inevitable when you implement nature's resiliency tools. In his thorough and thoughtful exploration of the New Biology, Sayer Ji illuminates: • the fascinating new science of food as information • the truth about cancer and heart disease screening and what real prevention looks like • how to reverse the most common forms of degeneration using food-based approaches • how the body extracts energy from sources other than food, including water and melanin; and • how to make sense of conflicting dietary recommendations and out-of-date food philosophies Encoded within every tissue of your body is your ability to regenerate. Unlock your radical resiliency through this roadmap for diet, exercise, stress reduction, and the cultivation of the environment in which you choose to live.

Tendon Regeneration

Tendon Regeneration [Pdf/ePub] eBook ISBN-10: 0128016000
Author: Manuela E Gomes,Rui L Reis,Márcia T Rodrigues
Publisher: Academic Press
File Size: 1450 KB
File Format: Pdf
Read Count: 3509955


Tendon Regeneration by Manuela E Gomes,Rui L Reis,Márcia T Rodrigues Book Resume:

Tendon Regeneration: Understanding Tissue Physiology and Development to Engineer Functional Substitutes is the first book to highlight the multi-disciplinary nature of this specialized field and the importance of collaboration between medical and engineering laboratories in the development of tissue-oriented products for tissue engineering and regenerative medicine (TERM) strategies. Beginning with a foundation in developmental biology, the book explores physiology, pathology, and surgical reconstruction, providing guidance on biological approaches that enhances tendon regeneration practices. Contributions from scientists, clinicians, and engineers who are the leading figures in their respective fields present recent findings in tendon stem cells, cell therapies, and scaffold treatments, as well as examples of pre-clinical models for translational therapies and a view of the future of the field. Provides an overview of tendon biology, disease, and tissue engineering approaches Presents modern, alternative approaches to developing functional tissue solutions discussed Includes valuable information for those interested in tissue engineering, tissue regeneration, tissue physiology, and regenerative medicine Explores physiology, pathology, and surgical reconstruction, building a natural progression that enhances tendon regeneration practices Covers recent findings in tendon stem cells, cell therapies, and scaffold treatments, as well as examples of pre-clinical models for translational therapies and a view of the future of the field

In Situ Tissue Regeneration

In Situ Tissue Regeneration [Pdf/ePub] eBook ISBN-10: 012802500X
Author: Sang Jin Lee,Anthony Atala,James J Yoo
Publisher: Academic Press
File Size: 1801 KB
File Format: Pdf
Read Count: 4268360


In Situ Tissue Regeneration by Sang Jin Lee,Anthony Atala,James J Yoo Book Resume:

In Situ Tissue Regeneration: Host Cell Recruitment and Biomaterial Design explores the body’s ability to mobilize endogenous stem cells to the site of injury and details the latest strategies developed for inducing and supporting the body’s own regenerating capacity. From the perspective of regenerative medicine and tissue engineering, this book describes the mechanism of host cell recruitment, cell sourcing, cellular and molecular roles in cell differentiation, navigational cues and niche signals, and a tissue-specific smart biomaterial system that can be applied to a wide range of therapies. The work is divided into four sections to provide a thorough overview and helpful hints for future discoveries: endogenous cell sources; biochemical and physical cues; smart biomaterial development; and applications. Explores the body’s ability to mobilize endogenous stem cells to the site of injury Details the latest strategies developed for inducing and supporting the body’s own regenerating capacity Presents smart biomaterials in cell-based tissue engineering applications—from the cell level to applications—in the first unified volume Features chapter authors and editors who are authorities in this emerging field Prioritizes a discussion of the future direction of smart biomaterials for in situ tissue regeneration, which will affect an emerging and lucrative industry

CNS Regeneration

CNS Regeneration [Pdf/ePub] eBook ISBN-10: 9780080556987
Author: Jeffrey Kordower,Mark H. Tuszynski
Publisher: Elsevier
File Size: 883 KB
File Format: Pdf
Read Count: 6154730


CNS Regeneration by Jeffrey Kordower,Mark H. Tuszynski Book Resume:

This second edition of CNS Regeneration updates the burgeoning field of regeneration in the Central Nervous System (CNS) from molecular, systems, and disease-based perspective. While the book covers numerous areas in detail, special emphasis is given to discussions of movement disorders such as Parkinson’s disease, Alzheimer’s disease, and spinal cord injury. Incorporates information gained from cutting-edge photomicroscopy techniques Includes current information on clinical trials Presents chapters on stem cells and other novel treatments for diseases of the CNS

Sport, Events, Tourism and Regeneration

Sport, Events, Tourism and Regeneration [Pdf/ePub] eBook ISBN-10: 1317244885
Author: Nicholas Wise,John Harris
Publisher: Routledge
File Size: 624 KB
File Format: Pdf
Read Count: 602436


Sport, Events, Tourism and Regeneration by Nicholas Wise,John Harris Book Resume:

Investments in sport, events and tourism in cities and wider regions are part of nascent regeneration strategies linked to transitioning economic bases and place images. While it is important to consider physical regeneration, there is a range of subsequent benefits and opportunities brought about through regeneration that considers social impacts, communities and how investments and developments influence how people interact in transformed spaces. This book brings together a collection focusing on the diverse range of approaches and perspectives of regeneration. Twelve chapters outline and bring together critical perspectives of regeneration from scholars in different parts of the world. This collection critically assesses some of the key factors impacting upon regeneration initiatives in relation to sport, events and tourism. By doing so, this book assesses if new opportunities have arisen from developments, increasing the demands and needs of locals and tourists, or if transformations result in exclusion - thus challenging who regeneration is for. This book will be valuable reading for students and academics interested in tourism studies, events planning, sport and leisure studies or development studies, as well as the wider social sciences.

Epigenetics and Regeneration

Epigenetics and Regeneration [Pdf/ePub] eBook ISBN-10: 0128148802
Author: ,
Publisher: Academic Press
File Size: 372 KB
File Format: Pdf
Read Count: 1872250


Epigenetics and Regeneration by , Book Resume:

Epigenetics and Regeneration compiles the first foundational reference on epigenetic mechanisms governing tissue development, repair, homeostasis, and regeneration, as well as pathways to employ these mechanisms in clinical practice and translational science. In this book, life science researchers, clinicians, and students will discover an interdisciplinary resource bringing together common themes in the field, background overviews, research methods, recent advances, and opportunities for drug discovery. Throughout this volume, special attention is paid to pre-clinical and first clinical studies aimed at increasing the regenerative potential of damaged tissues by epigenetic drugs, as well as innovative, discipline spanning strategies to enhance cell reprogramming. As an all-inclusive, evidence-based volume, Epigenetics and Regeneration will stimulate discussion and boost new research in this fascinating and impactful area of translational epigenetics. Provides a foundational overview of epigenetics in regenerative medicine Examines epigenetic components of tissue regeneration for a variety of organ systems and tissue types, as well as current attempts to employ these mechanisms in clinical practice Offers researchers, students, clinicians, and pharmacologists the tools they need to enhance tissue development, repair, homeostasis, and regeneration and explore new epigenetic therapeutic pathways Features chapter contributions from leading international researchers and clinicians in the fields of epigenetics and regenerative medicine

"Catch if you can your country’s moment"

ISBN-10: 1443810584
Author: William S. Waddell
Publisher: Cambridge Scholars Publishing
File Size: 1822 KB
File Format: Pdf
Read Count: 9318500


"Catch if you can your country’s moment" by William S. Waddell Book Resume:

The eight essays in this collection explore the work of Adrienne Rich, one of America’s most significant living writers and a poet and a public intellectual with a substantial audience both inside and outside the academy. Taken together, the essays argue for a shift in the perceived center of gravity of Rich’s career, from the passionate and eloquent poems of a largely personal feminist awakening, from the mid 60s to the early 80s, to the equally (if differently) passionate and eloquent poems of a more broadly public re-imagination of our country and its history, beginning with her work of the mid 1980s. Rich has remained committed to the reconstruction of poetry’s place in public as well as private life, nationally and globally. From varied perspectives, accessible to the common reader as well as the specialist, the collection addresses Rich’s negotiation of the boundary between these public and private spheres and the potential of poetry as a revolutionary medium and alternate epistemology, a means, as the title expresses it, of recovery and regeneration. Rich has aimed always, as the last lines of her poem “Planetarium” (1968) have it, at “the relief of the body / and the reconstruction of the mind,” and this collection works to describe her effort to extend the reach of that healing motive across a continent and a culture. "In these eight keenly executed essays edited by William Waddell, we see Rich finally removing those “asbestos gloves” once used to handle sizzling political topics. Critics in this volume show Adrienne Rich struggling barehanded with changing poetic strategies, complex new subject positions and the relations of power and cultural practice in the constitution of history. Transformative cartographer of words and perceptions, Rich, as Waddell argues, outlines “a method for redefining American space,” remapping North American culture for the marginalized, the repressed and the resistant. Waddell’s collection celebrates the polyphony of politics and aesthetics in Rich’s work, shaping for the reader an ethical discourse intensively visible, for the first time, in volumes such as An Atlas of the Difficult World: Poems 1988-1991, but equally present throughout Rich’s prose and poetry." Mary Lynn Broe, Caroline Werner Gannett Professor, Rochester Institute of Technology

Urban Regeneration

Urban Regeneration [Pdf/ePub] eBook ISBN-10: 3030047113
Author: Steffen Lehmann
Publisher: Springer
File Size: 966 KB
File Format: Pdf
Read Count: 6514047


Urban Regeneration by Steffen Lehmann Book Resume:

Urban Regeneration — A Manifesto for transforming UK Cities in the Age of Climate Change explores and offers guidance on the complex process of how to transform cities, continuing the unfinished project of the seminal 1999 text Towards an Urban Renaissance. It is a 21st-century manifesto of urban principles compiled by a prominent urbanist, for the regeneration of UK cities, focusing on the characteristics of a ‘good place’ and the strategies of sustainable urbanism. It asks readers to consider how we can best transform the derelict, abandoned and run-down parts of cities back into places where people want to live, work and play. The book frames an architecture of re-use that translates and combines the complex ‘science of cities’ and the art of urban and architectural design into actionable and practical guidance on how to regenerate cities. Fascinated by the typology and value of the compact UK and European city model, Lehmann introduces the concept of ‘high density without high buildings’ as a solution that will make our cities compact, walkable, mixed-use and vibrant again.

Kidney Development, Disease, Repair and Regeneration

Kidney Development, Disease, Repair and Regeneration [Pdf/ePub] eBook ISBN-10: 012800438X
Author: Melissa Helen Little
Publisher: Academic Press
File Size: 993 KB
File Format: Pdf
Read Count: 6109219


Kidney Development, Disease, Repair and Regeneration by Melissa Helen Little Book Resume:

Kidney Development, Disease, Repair and Regeneration focuses on the molecular and cellular basis of kidney development, exploring the origins of kidney lineages, the development of kidney tissue subcompartments, as well as the genetic and environmental regulation of kidney development. Special coverage is given to kidney stem cells and possible steps towards kidney repair and regeneration. Emphasis is placed on the fetal origins of postnatal renal disease and our current understanding of the molecular basis of damage and repair. Biomedical researchers across experimental nephrology and developmental biology will find this a key reference for learning how the underlying developmental mechanisms of the kidney will lead to greater advances in regenerative medicine within nephrology. Offers researchers a single comprehensive resource written by leaders from both the developmental biology and the experimental nephrology communities Focuses on understanding the molecular basis of organogenesis in the kidney as well as how this can be affected both genetically and environmentally Explains the underlying developmental mechanisms which influence the kidney’s inherent repair capacity Demonstrates how a deeper understanding of mechanisms will lead to greater advances in regenerative medicine

The Routledge Companion to Urban Regeneration

The Routledge Companion to Urban Regeneration [Pdf/ePub] eBook ISBN-10: 1136266542
Author: Michael E. Leary,John McCarthy
Publisher: Routledge
File Size: 1212 KB
File Format: Pdf
Read Count: 2305516


The Routledge Companion to Urban Regeneration by Michael E. Leary,John McCarthy Book Resume:

In the past decade, urban regeneration policy makers and practitioners have faced a number of difficult challenges, such as sustainability, budgetary constraints, demands for community involvement and rapid urbanization in the Global South. Urban regeneration remains a high profile and important field of government-led intervention, and policy and practice continue to adapt to the fresh challenges and opportunities of the 21st century, as well as confronting long standing intractable urban problems and dilemmas. This Companion provides cutting edge critical review and synthesis of recent conceptual, policy and practical developments within the field. With contributions from 70 international experts within the field, it explores the meaning of ‘urban regeneration’ in differing national contexts, asking questions and providing informed discussion and analyses to illuminate how an apparently disparate field of research, policy and practice can be rendered coherent, drawing out common themes and significant differences. The Companion is divided into six sections, exploring: globalization and neo-liberal perspectives on urban regeneration; emerging reconceptualizations of regeneration; public infrastructure and public space; housing and cosmopolitan communities; community centred regeneration; and culture-led regeneration. The concluding chapter considers the future of urban regeneration and proposes a nine-point research agenda. This Companion assembles a diversity of approaches and insights in one comprehensive volume to provide a state of the art review of the field. It is a valuable resource for both advanced undergraduate and postgraduate students in Urban Planning, Built Environment, Urban Studies and Urban Regeneration, as well as academics, practitioners and politicians.

Tissue and Organ Regeneration

Tissue and Organ Regeneration [Pdf/ePub] eBook ISBN-10: 981441168X
Author: Lijie Grace Zhang,Ali Khademhosseini,Thomas Webster
Publisher: CRC Press
File Size: 323 KB
File Format: Pdf
Read Count: 8767410


Tissue and Organ Regeneration by Lijie Grace Zhang,Ali Khademhosseini,Thomas Webster Book Resume:

Tissue engineering aims to develop biological substitutes that restore, maintain, or improve damaged tissue and organ functionality. To date, numerous stem cells and biomaterials have been explored for a variety of tissue and organ regeneration. The challenge for existing stem cell–based techniques is that current therapies lack controlled environments that are crucial for regulating stem cell engraftment and differentiation in vivo, because stem cells are rather sensitive to even minute changes in their environment. Micro- and nanotechnology hold great potential to fabricate biomimetic spatiotemporally controlled scaffolds as well as control stem cell behavior and fate by micro- and nanoscale cues. This book presents the latest micro- and nanotechnologies used to manipulate stem cell behaviors, which is a critical area for regenerative medicine. Moreover, it covers and details cutting-edge research in nano- and microfabrication techniques and biomaterials for the regeneration of various tissues and organs, such as bone, cartilage, craniofacial, osteochondral, muscle, bladder, cardiac, and vascular tissues.

Regenerative Nephrology

Regenerative Nephrology [Pdf/ePub] eBook ISBN-10: 9780123809292
Author: Michael S. Goligorsky
Publisher: Academic Press
File Size: 529 KB
File Format: Pdf
Read Count: 1347435


Regenerative Nephrology by Michael S. Goligorsky Book Resume:

Progression of chronic diseases in general and chronic kidney disease in particular has been traditionally viewed in the light of various contributors to development of glomerulosclerosis and tubulointerstitial scarring culminating in renal fibrosis. Indeed, this dogma prevailed for decades underscoring experimental attempts to halt fibrotic processes. Breakthrough investigations of the past few years on stem/progenitor cell involvement in organ regeneration caused a conceptual shift in tackling the mechanisms of nephrosclerosis. It has become clear that the rate of progression of chronic kidney disease is the net sum of the opposing trends: degenerative fibrotic processes and regenerative repair mechanisms. The latter part of this equation has been by and large ignored for years and only recently attracted investigative attention. This book revisits the problem of kidney disease by focusing on regenerative mechanisms in renal repair and on the ways these regenerative processes can become subverted by an intrinsic disease process eventuating in its progression. Cutting-edge investigations are summarized by the most experienced international team of experts. Presents a comprehensive, translational source for all aspects of renal stem cells, tissue regeneration, and stem cell therapies for renal diseases in one reference work. This will ultimately result in time savings for academic, medical and pharma researchers Experts in the renal stem cell system in kidney repair and regeneration take readers from the bench research to new therapeutic approaches, providing a common language for nephrology researchers, fellows and other stem cell researchers. This enables the discussion of development of stem cells and their use in the repair and regeneration of the kidney

Tourism, Culture and Regeneration

Tourism, Culture and Regeneration [Pdf/ePub] eBook ISBN-10: 1845931319
Author: Melanie K. Smith
Publisher: CABI
File Size: 851 KB
File Format: Pdf
Read Count: 8337112


Tourism, Culture and Regeneration by Melanie K. Smith Book Resume:

Sustainable and integrated regeneration in the context of culture and tourism is explored for the first time within this book. The text is enhanced by international case studies.

Culture-Led Urban Regeneration in South Korea

Culture-Led Urban Regeneration in South Korea [Pdf/ePub] eBook ISBN-10: 1648892035
Author: Milyung Son
Publisher: Vernon Press
File Size: 965 KB
File Format: Pdf
Read Count: 4739041


Culture-Led Urban Regeneration in South Korea by Milyung Son Book Resume:

There is a continuing academic and policy interest in the potential for culture-based urban regeneration across the world. Such regeneration is intended to attract investment, re-imagine spaces and create employment, business and urban planning opportunities. This book seeks to examine the use of culture and arts in the urban regeneration sphere of South Korea. Specifically, a one-year-long cultural event (Culture City of East Asia) is used as a case study for exploring wider debates around and understandings of the relationships between culture-led urban regeneration initiatives and the impacts on communities in South Korea. Despite the proliferation of culture-led initiatives aiming to tackle broad social issues, there is a lack of in-depth research into the efficacy of such urban regeneration. Previous researches have asked such questions as: What benefits can cultural elements (e.g. mega-events or signature buildings) bring into a city? What is the role of culture in economic development (e.g. tourism and internal investment)? What is the economic value of cultural goods and services? This is not to say that such questions should be the only concerns in assessing a culture-led urban regeneration strategy. However, the evaluation process of culture-led regeneration frequently fails to ask questions about the impact on human communities: Are cultural resources being used to spread culture, or just to focus on economic development? Are cultural initiatives like mega-events being used to benefit local citizens? How can residents shape a culture-led regeneration strategy? This book is intent on examining residents’ opinions and perspectives about culture-led urban regeneration. It recognizes how culture-led regeneration schemes interact with local communities, focusing on the actual views of local people rather than being coldly theoretical.

Organ Repair and Regeneration

Organ Repair and Regeneration [Pdf/ePub] eBook ISBN-10: 0128194529
Author: Giuseppe Orlando,Shaf Keshavjee
Publisher: Academic Press
File Size: 1929 KB
File Format: Pdf
Read Count: 887577


Organ Repair and Regeneration by Giuseppe Orlando,Shaf Keshavjee Book Resume:

Organ Repair and Regeneration: Preserving Organs in the Regenerative Medicine Era encompasses updates on all organs, from the kidneys, to the lungs, liver, pancreas, intestines, and beyond. Chapters cover the pathophysiology of ischemia-reperfusion, repairing organs with MSC, repairing cardiac allografts in situ, and much more. The book conceptualizes the idea that the modern approach to organ preservation is ante literam, a form of organ repair and regeneration which, per se, is referred to as a field of health sciences under the umbrella of regenerative medicine. This book demonstrates the merging of regenerative medicine and organ transplantation. Covers all aspects of organ preservation, repair and regeneration Addresses the repair of organs that experience an Ischemia/Reperfusion (I/R) injury, those that are intended for transplantation, and specific issues related to each organ Presented by editors and authors who are physicians, surgeons and researchers in the field of organ transplantation and regenerative medicine

Estate Regeneration

Estate Regeneration [Pdf/ePub] eBook ISBN-10: 1000071391
Author: Brendan Kilpatrick,Manisha Patel
Publisher: Routledge
File Size: 1694 KB
File Format: Pdf
Read Count: 4348761


Estate Regeneration by Brendan Kilpatrick,Manisha Patel Book Resume:

One hundred years ago, the Addison Act created the circumstances for the large scale construction of municipal housing in the UK. This would lead to the most prolific phases of housing estate building the country has ever seen. The legacy of this historic period has been tackled for the last twenty-five years as these estates began to suffer from misguided allocation policies, systemic building and fabric failure and financial austerity. A series of estate regeneration programmes sought to rectify the mistakes of the past. Estate Regeneration describes 24 of these regeneration schemes from across the UK and the design philosophy and resident engagement which formed each new community. A number of essays from a wide range of industry experts amplify the learning experience from some key estate regeneration initiatives and provide observations on the broader issues of this sector of the housing market. Regeneration is inevitable; it is a matter of the form which regeneration should take. The information presented here is a guide to an intuitive approach to estate regeneration which commences with the derivation of strong urban design principles and is guided by real community engagement. The experience presented seeks to learn from the mistakes of the past to create the best possible platform for regeneration of the housing estates of the future.


ReGeneration [Pdf/ePub] eBook ISBN-10: 1486620701
Author: Miriam Charter
Publisher: Word Alive Press
File Size: 1585 KB
File Format: Pdf
Read Count: 7449271


ReGeneration by Miriam Charter Book Resume:

Story is a powerful tool for teaching and learning. This is a book of stories about ministry in the underground church of communist Romania (1980s). It introduces a never-ending story about the regenerative process of true discipleship, which reaches today to the second, third, and fourth generations. These stories will inspire deeper reflection on challenging missional issues that will certainly be encountered by the next generation of international workers.


Seeds [Pdf/ePub] eBook ISBN-10: 9780851999470
Author: Michael Fenner
Publisher: CABI
File Size: 730 KB
File Format: Pdf
Read Count: 6557326


Seeds by Michael Fenner Book Resume:

This new edition of a successful text, originally published in 1992, has been thoroughly revised and updated to include recent advances. In addition, new chapters have been introduced to ensure comprehensive coverage of all aspects of seed ecology. These include evolutionary ecology of seedsize, the roles of fire and of gaps in regeneration and seedling colonization. Chapters are written by internationally acknowledged experts to give a comprehensive overview of all aspects of seed ecology which will be invaluable to advanced students and researchers in seed science and plantecology.

Neuronal Degeneration and Regeneration: From Basic Mechanisms to Prospects for Therapy

Neuronal Degeneration and Regeneration: From Basic Mechanisms to Prospects for Therapy [Pdf/ePub] eBook ISBN-10: 9780080862422
Author: F.W. Van Leeuwen,A. Salehi,R.J. Giger,A.J.G.D. Holtmaat,J. Verhaagen
Publisher: Elsevier
File Size: 1123 KB
File Format: Pdf
Read Count: 1305589


Neuronal Degeneration and Regeneration: From Basic Mechanisms to Prospects for Therapy by F.W. Van Leeuwen,A. Salehi,R.J. Giger,A.J.G.D. Holtmaat,J. Verhaagen Book Resume:

This book is the result of the 20th International Summer School in Brain Research, organized in August 1997 in Amsterdam, by the Netherlands Institute for Brain Research at the Royal Netherlands Academy of Sciences. It is the first book that provides a complete overview of the field of neurodegeneration and regeneration including spinal cord injury, neurodegenerative diseases and therapy. Divided into five sections, the first two sections give an overview of fundamental research on nerve cell death, neuronal survival, neurite outgrowth and guidance. Extensive attention is given to the role of neurotrophins, their receptor tyrosine kinases and cell-adhesion molecules in development and regeneration of the nervous system. The third section of the book is devoted to research involving human neurodegenerative diseases and emerging treatment strategies. Section four focusses on recent advances in the understanding of pathophysiological mechanisms underlying neurodegenerative diseases, including Alzheimer's, Parkinson's and Huntington's diseases along with prion diseases. Novel insights into the neuropathological hallmarks of these diseases, as well as into transgenic animal models, the involvement of environmental factors, and genomic and mRNA changes that can cause neurodegeneration. The final section of this volume reveals recent developments in the use of cell and gene therapy to treat neurodegenerative disease and lesion-related deficits. Implantation of genetically modified cells, direct gene transfer with viral vectors and the first clinical trials with encapsulated genetically modified cells in patients suffering from amyotrophic lateral scelerosis are examples of new therapeutic strategies treating neurodegenerative diseases. The book is of particular interest to departments of neuroscience, neurological clinics and departments, the pharmalogical industry and medical libraries.